Treatment of Severe Imipramine Poisoning

Treatment of severe imipramine poisoning.

The clinical effects and treatment of imipramine and amitriptyline poisoning have been reviewed by Giles (1963) and Steel, O'Duffy, and Brown (1967). The majority of cases are mild and recover spontaneously. The severe case is characterized by coma, convulsions, and cardiac arrhythmias. There is the added risk of respiratory depression and hypotension. Poisoning is severe if the dose of the dru...

Amitriptyline and imipramine poisoning in children.

The increasing number of children admitted to this hospital with poisoning by tricyclic antidepressants is causing concern. Of 60 children admitted between January 1966 and July 1973, half were admitted in the last 18 months. In 60% of these patients the tricyclic compounds had been prescribed for nocturnal enuresis. One child aged 2 years and 4 months died of imipramine poisoning. It is impera...

Severe meprobamate poisoning: successful treatment with haemoperfusion.

Charcoal haemoperfusion used to treat a 56-year-old woman who had taken a very large overdose of meprobamate was followed by fully recovery. The plasma clearance of meprobamate was 153 ml/min and this compares favourably with values obtained for haemodialysis. The indications for haemoperfusion are reviewed.

Imipramine poisoning: survival of a child after prolonged cardiac massage.

Treatment of severe poisoning with slow release theophylline.